A Drosophila systems model of pentylenetetrazole induced locomotor plasticity responsive to antiepileptic drugs
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منابع مشابه
Validation of the Zebrafish Pentylenetetrazol Seizure Model: Locomotor versus Electrographic Responses to Antiepileptic Drugs
Zebrafish have recently emerged as an attractive in vivo model for epilepsy. Seven-day-old zebrafish larvae exposed to the GABA(A) antagonist pentylenetetrazol (PTZ) exhibit increased locomotor activity, seizure-like behavior, and epileptiform electrographic activity. A previous study showed that 12 out of 13 antiepileptic drugs (AEDs) suppressed PTZ-mediated increases in larval movement, indic...
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Quinine, is an anti-malarial drug that specifically blocks connexin 36 (Cx36) at gap junction channels. Quinine has suppressed ictal epileptiform activity in vitro without decreasing neuronal excitability. Thus, we considered the possible anticonvulsant effects of quinine in the pentylenetetrazole (PTZ) model of seizure. Moreover, we studied the hypnotic effect and locomotor activity of quinine...
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La therapeutique ant epileptique de longue duree provoque une profonde modification du metabolisme de la vitamine B et notamment une acceleration du catabolisme de celle-ci. Les auteurs rapportent un cas de ce type particulier d'osteomalacie et la revue de la litterature leur permet de souligner trois points essentiels: 1 ) les besoins journaliers de la vitamine B sontaccrus chez les enfan...
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Mothers exposed to Antiepileptic drugs (AEDs) are at high risk to born babies with orofacial malformations such as cleft lips. About 9 percent of congenital abnormalities in babies of mothers with epilepsy relates to orofacial abnormalities. Maintaining safe antiepileptic drugs for millions of mothers with epilepsy is very important. Researches show that new AEDs have less side effects than the...
متن کاملGender Differences in a Drosophila Transcriptomic Model of Chronic Pentylenetetrazole Induced Behavioral Deficit
A male Drosophila model of locomotor deficit induced by chronic pentylenetetrazole (PTZ), a proconvulsant used to model epileptogenesis in rodents, has recently been described. Antiepileptic drugs (AEDs) ameliorate development of this behavioral abnormality. Time-series of microarray profiling of heads of male flies treated with PTZ has shown epileptogenesis-like transcriptomic perturbation in ...
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ژورنال
عنوان ژورنال: BMC Systems Biology
سال: 2009
ISSN: 1752-0509
DOI: 10.1186/1752-0509-3-11